Effects of Lifestyle Intervention in the Biological Aging in Prediabetes
Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age30-80
SponsorKing Saud University
About this trial
Lifestyle modifications, including dietary changes and increased physical activity, play a crucial role in controlling complications to reduce or eliminate them. As well as controlling disturbances in biochemical markers such as DNAm PhenoAge, and signs of aging such as circulating sclerostin (SOST) and growth differentiation factor 15 (GDF15). This study seeks to address this dilemma by focusing on specific groups of elderly Saudis with prediabetes . Lifestyle changes in elderly Saudis with prediabetes show promise in reducing or eliminating complications. The potential insights derived from this research extend beyond academia, offering tangible benefits for clinical practice and public health
The proposed study will be implemented to achieve the following objective:
1. To determine changes in DNAm PhenoAge of elderly Saudis with prediabetes who underwent a 6-month lifestyle modification program. 2. To determine changes in other candidate senescence markers such as circulating sclerostin (SOST) and growth differentiation factor 15 (GDF15) of elderly Saudis with prediabetes who underwent a 6-month lifestyle modification program.
Eligibility criteria
Qualifiers
Clinical diagnosis of pre-diabetes for all Saudis aged 30 years and above, males and females
They must be able to exercise and be able to follow a diet
Disqualifiers
Insulin-dependent diabetes and non-diabetic patients
People with diseases that prevent them from participating and doing exercises
Trial design
Treatments tested in this trial
- Providing nutritional counselling
- counseling on physical activity
Treatment groups
500 Participants
are divided into 2 treatment groupsLocations
Sponsors and collaborators
Source ClinicalTrials.gov