Pain is a major complaint in hemodialysis (HD) patients. Concentrations of parathyroid hormone (PTH) \>250 pg/ml are associated with chronic pain. Visual Analogue Scale (VAS) score which is used to assess the pain severity is positively related to PTH levels. This study is aimed to assess the effects of multiple mega dosages vitamin D supplementations in HD patients with chronic pain. It's a single-center, parallel, double-blind randomized control trial that administrations of 576,000 IU once a week of vitamin D3 for 4 weeks or placebo are for 120 eligible subjects. VAS and laboratory tests including serum concentrations of 25(OH)D, calcium, phosphorus, PTH and C-reactive protein will be evaluated.
Haemodialysis subject ≥ 20 years old
iPTH > 250 pg/mL
Chronic pain with visual analogue scale (VAS) score ≥ 4
Voluntary to check serum 25(OH)D levels two times by his/her own payment during the study
Used to participate in other clinical trials
Chronic liver disease
Sarcoidosis or multiple myeloma