Effects of Pomegranate Juice on Ulcerative Colitis
ConditionUlcerative Colitis (Disorder)
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorUniversity of California, Los Angeles
About this trial
The purpose of this study is to determine whether consumption of 237 ml of pomegranate juice daily for 8 weeks will:
1. lower inflammation (in the gut as well as generally in the body) and improve your overall quality of life 2. affect the microbes living in the gut (gut microbiota)
Eligibility criteria
Qualifiers
• Adults ≥ 18 yo
Following a low-polyphenol and fiber diet (< 3 servings of fruits/vegetables per day)
Mild-to-moderate UC at the time of screening (2 ≤ partial Mayo scores ≤ 5)
Supportive evidence of active inflammation (hsCRP >1 mg/L, fecal calprotectin >50 µg/g stool, or abnormal lower endoscopy) in individuals with biopsy-proven UC
Disqualifiers
• Non-English speaker
Vegetarian/vegan
Known pomegranate allergy
Documented chronic disease besides UC, including diabetes, renal or liver diseases, metabolic syndrome, active cancer, MI or stroke, history of gastric bypass
Trial design
Treatments tested in this trial
- pomegranate juice -> habitual diet
- habitual diet -> pomegranate juice
Treatment groups
30 Participants
are divided into 2 treatment groupsSponsors and collaborators
University of California, Los Angeles
Lead sponsor
National Institutes of Health (NIH)
Collaborator
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Collaborator
Source ClinicalTrials.gov