Effects of Positive End-Expiratory Pressure (PEEP) and Prone Positioning in Healthy Volunteers on Venous Hemodynamics Including the Venous Excess Ultrasound (VExUS) Score

ConditionVenous Hemodynamics

Trial statusRecruiting

Trial phaseNot applicable

Trial typeInterventional

Biological sexAll

Age18+

SponsorUniversity Hospital, Basel, Switzerland

About this trial

The hemodynamic effects of proning and PEEP may vary depending on pre- existing cardiac function, lung mechanics, and volume status, and the available evidence remains conflicting. The impact on the VExUS score of these manoeuvres is unclear. This study aims to assess the effects of PEEP in supine and prone position on the VExUS score as well as echocardiographic parameters in a cohort of healthy volunteers.

Eligibility criteria

Qualifiers

Voluntary participants ≥ 18 years in good overall health with no relevant organ dysfunction in their medical history and signed informed consent form.

Disqualifiers

Non-French or non-German speakers

Unable to provide informed consent

Body mass index > 40kg/m

Self-reported pregnancy

Trial design

Treatments tested in this trial

application of PEEP: starting PEEP = 15 mbar
application of PEEP: starting PEEP = 0 mbar

Treatment groups

40 Participants

are divided into 2 treatment groups

Sponsors and collaborators

University Hospital, Basel, Switzerland

Lead sponsor

Source ClinicalTrials.gov