The CHLOR-DETOX study is a single-centre, double-blind, prospective, interventional, controlled, exploratory pilot study on subjects environmentally exposed to the organochlorine pesticide (kepone or chlordecone, CLD) in the French Caribbean (Martinique island). To our best knowledge, it is the first clinical trial in such subjects evaluating the potential effect of oral probiotic intake (Limosilactobacillus reuteri) on the reduction of CLD plasma levels (chlordeconemia) and fecal excretion, thus concurring to the reduction of CLD toxicity in study subjects.
Male or female, 18 years of age or older
Seen in clinical toxicology consultation at the CHU of Martinique during the study period
With an initial chlordeconemia > 1μg/L on a test less than 1 month old at the time of study inclusion
Affiliated to a social security scheme
History of cancer
Recent infections less than 6 months old
Known digestive diseases: chronic diarrhoea, ulcerative colitis, Crohn's disease, pancreatitis
Digestive procedures less than 6 months old.
University Hospital Center of Martinique
Lead sponsor
BioGaia AB
Collaborator
University Hospital, Limoges
Collaborator
Regional Health Agency, Martinique
Collaborator
Biological Resource Centre, Martinique
Collaborator
Reims University hospital
Collaborator