This is a longitudinal study to examine the effects of a short-term training program on neurofilamet and GFAP plasma levels. Participants will be divided in two groups: control group (moderate aerobic training) and active group (resistance training). The change in biomarkers will be analyzed pre and post intervention in both groups. Differences between groups will be also evaluated by investigators.
- Diagnosis of multiple sclerosis according to the 2017 Mc Donald criteria (Thompson A et al).
- Age > 18 years - up to no age limit
- Disability assessed by the EDSS (Expanded disability status scale) with a score less than or equal to 4.
- Clinical stability. Not having had an outbreak of the disease in the last 6 months.
- Patients with a high level of physical activity according to the International Physical Activity Questionnaire(IPAQ) or latest WHO (World Health Organization) recommendations on physical activity
- Pregnant or breastfeeding patients.
- Concomitant pathologies that limit the performance of physical exercise
Hospital Clínico Universitario de Valladolid
Lead sponsor
European University Miguel de Cervantes
Collaborator