Effects of Resistance Training on Sarcopenia in Older Patients With Chronic Heart Failure
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age60+
SponsorKieu Nguyen Dang Phuong
About this trial
The goal of study is to evaluate the effects of an eight-week machine-based resistance training program on managing sarcopenia in older outpatients with chronic heart failure (HF) at Military Hospital 175.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Aged ≥ 60 years old
Meet the diagnostic criteria of 2019 AWGS2 sarcopenia, can be diagnosed once meeting (1) + (2) or (1) + (3) or (1) + (2) + (3): (1) Appendicular skeletal muscle mass (ASM): dual-energy X-ray absorptiometry (DXA) (male <7.0 kg/m², female <5.7 kg/m²). (2) Muscle strength: handgrip strength (male <28.0 kg, female <18.0 kg). (3) Physical performance: 6-meter walking speed <1.0 m/s.
Meet the diagnostic criteria of heart failure following ESC 2021.
Clearly understand the content and purpose of the study and sign the informed consent form.
Disqualifiers
Early stage after acute coronary syndrome (within the first 2 days)
Unstable coronary artery disease
Decompensated heart failure
Acute venous thrombosis or recent arterial embolism (pulmonary or systemic)
Trial design
Design model
Parallel
Treatments tested in this trial
Machine-based Resistance Training
Other interventionThe participants will receive HF treatment as prescribed by cardiologists. If participants have any additional medical conditions, their existing medications or treatments should continue. They are also asked to maintain their usual physical activity, exercise routines, and dietary habits, without making changes outside of the study intervention. At the beginning, patients participating in resistance training should complete a pretest of one-repetition maximum (1-RM) to assess muscle strength, which will be used by a professional physical therapist to develop an individualized prescription. The specific movements are as follows: (1) leg press and (2) calf raise by Proxomed Compass 540 (Germany); (3) leg curl, (4) chest press, (5) push up, (6) seated row by HUR machine (US). During the 8 weeks, subjects will train 3 non-consecutive days/week with intensity 30%1-RM to 60% 1-RM, 3 sets/one excercise with 8-12 repetitions.
Treatment groups
146 Participants
are divided into 2 treatment groupsGroup A: Usual Care Group (US)No intervention 0 interventions
Group B: Machine-based Resistance Training GroupOther 1 intervention
Trial outcomes
Primary outcomes
1
The change of muscle strength
The change of muscle strength will be evaluated using handgrip strength, measured in kilograms. Each hand will be tested twice with a Jamar Hydraulic Hand Dynamometer (USA), and the highest value will be recorded.
Time frame
Baseline and 8 weeksSecondary outcomes
1
The change of the five-times sit-to-stand test
The five-times sit-to-stand test is timed in seconds. Participants will sit in a chair without armrests, ensuring their back and lower legs are straight, with their arms crossed over their chest. They will then stand up and sit down as quickly as possible. The time is recorded using a stopwatch, beginning when the participants stand for the first time and ending when they sit down for the fifth time.
Time frame
Baseline and 8 weeks2
The change of gait speed
Gait speed is measured in meters per second. Participants will walk at their usual pace over a 6-meter distance, and gait speed will be calculated using the formula v = s/t, where t is the time in seconds and s is the distance (6 meters).
Time frame
Baseline and 8 weeksSponsors and contacts
Click on the lead sponsor to view all of their trials.
Kieu Nguyen Dang Phuong
Lead sponsor
University of Medicine and Pharmacy at Ho Chi Minh City
Sponsor institution
Source ClinicalTrials.gov