Effects of Substance P on Headache Induction in Healthy Individuals

ConditionHealthy Volunteers Only

Trial statusNot yet recruiting

Trial phaseNot applicable

Trial typeInterventional

Biological sexAll

Age18-65

SponsorDanish Headache Center

About this trial

Substance P is a signaling molecule that has been implicated in the pathogenesis of headache. This study aims to ascertain whether administration of substance P can induce headache in healthy adults.

Eligibility criteria

Qualifiers

Age 18 to 65 years of age upon entry into screening

A body weight of 50 to 100 kg

Provision of informed consent prior to initiation of any study-specific activities/procedures.

Disqualifiers

Any history of a primary or secondary headache disorder, except for infrequent episodic tensiontype headache

Any first-degree relatives with a history of a primary headache disorder, except for infrequent episodic tension-type headache

Any history of moderate to severe traumatic brain injury

Any history of cardiovascular disease, including cerebrovascular diseases

Trial design

Treatments tested in this trial

Substance P
Placebo

Treatment groups

21 Participants

are divided into 2 treatment groups

Sponsors and collaborators

Danish Headache Center

Lead sponsor

Source ClinicalTrials.gov