Effects of Transcranial Direct Current Stimulation Combined With Nordic Walking on Gait and Balance in Parkinson's Disease

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age50-75
SponsorUniversidade Metodista de Piracicaba

About this trial

Parkinson's disease can cause slow or unsteady walking and balance problems that raise the risk of falls. This study will test whether adding a gentle, non-invasive brain stimulation called transcranial direct current stimulation (tDCS) during a supervised Nordic Walking program improves mobility in people with Parkinson's disease. Participants will be randomly assigned to receive either active tDCS or an inactive (sham) procedure that feels the same but does not deliver current, while both groups complete the same supervised walking program. Sessions occur three times per week for four weeks. We will measure walking speed with a 10-Meter Walk Test as the main outcome, and also evaluate balance, motor symptoms, quality of life, and any side effects. We expect that tDCS given during the walking sessions will help people walk faster and feel steadier compared with the walking program alone.

Eligibility criteria

Qualifiers

Idiopathic Parkinson's disease (e.g., UK Brain Bank criteria)

Hoehn & Yahr stage II-IV (on medication)

Stable antiparkinsonian medication for ≥4 weeks before enrollment

Slowed gait phenotype (e.g., ≥6 seconds on 10-Meter Walk at preferred speed)

Disqualifiers

Contraindications to tDCS: implanted cranial/brain devices (e.g., DBS), metal in the skull (excluding dental), active skin disease/lesions at electrode sites, uncontrolled epilepsy or history of seizure in the past 12 months

Unstable medical or psychiatric conditions that preclude safe participation (e.g., uncontrolled hypertension, recent cardiovascular events, severe orthostatic hypotension with syncope)

Severe freezing of gait or fall risk that prevents safe participation in supervised Nordic Walking, as judged by the clinical team

Severe musculoskeletal or vestibular disorders that limit walking with poles; severe uncorrected visual impairment

Trial design

Treatments tested in this trial

  • Transcranial Direct Current Stimulation (tDCS), active
  • Sham transcranial Direct Current Stimulation
  • Standardized Nordic Walking program

Treatment groups

40 Participants
are divided into 2 treatment groups