Assessment of the effects of vibrating mesh nebulisation versus jet nebulisation on the electrical activity of the muscles involved in breathing (neural respiratory drive), breathing mechanics (respiratory impedance measured by forced oscillation technique), respiratory flow, heart rate and rhythm, spirometry and breathlessness symptoms in patients with chronic obstructive pulmonary disease who require non-invasive ventilation.
Patients with COPD receiving home non-invasive ventilation for chronic respiratory failure under the Lane Fox Respiratory Service at Guy's and St Thomas' NHS Foundation Trust
Tolerating home non-invasive ventilation for at least 4 hours/24 hours
Aged 18-80 years old
Able to communicate symptom burden to the research team
Congestive cardiac failure
Significant cardiovascular disease
End-stage malignancy
End-stage renal failure