High concentrations of parathyroid hormone (PTH) are common in patients with hepatocellular carcinoma (HCC). This study is aimed to investigate effects of vitamin D status and its multiple mega-dosage supplementation on PTH and clinical outcomes in HCC patients before and after hepatectomy. It's a single-center, prospective, parallel, double-blind, placebo-controlled study for 120 eligible subjects. The subjects will receive consecutively 3-day intervention treatments from 7th day before surgery. 30-day postoperative mortality, postoperative complications, and laboratory data will be evaluated.
1. ≥ 20-year HCC subjects receiving laparoscopic hepatectomy
2.Sign the informed consent
1. Using estrogen drugs, bisphosphonates, or drugs for bone disease.
2. Consume calcium tablets within 2 weeks before operation
3. Sarcoidosis, multiple myeloma
4. Pregnant women or plan to become pregnant within 3 months after surgery