Chronic kidney disease (CKD) consists of kidney damage, with consequent progressive and irreversible loss of kidney function. In the early stages of the disease, a reduction in circulating levels of the α-klotho protein is already observed, which is related to worsening renal function. Therapeutic strategies that increase serum levels of α-klotho may be of great value in the treatment of CKD. Electrical stimulation contributes to the reduction of reactive oxygen species, DNA damage and improves the effectiveness rate of dialysis, suggesting a systemic effect in patients with terminal CKD. The objective of this study is to evaluate the effects of whole body electrical stimulation on renal function and physical capacity in patients with CKD not dependent on dialysis.
Patients diagnosed with CKD (≥ 3 months) in stages 3-4 (GFR between 59 and 15 ml/min/1.73m2);
Age between 18 and 80 years old;
Functional capacity ≥ 300 meters in the six-minute walk test.
Cognitive dysfunction that prevents assessments from being carried out or inability to understand and sign the informed consent form;
Intolerance to electrical stimulator and/or changes in skin sensitivity;
Skin injuries or burns where the electrodes are positioned;
Patients with stroke sequelae;
Federal University of Health Science of Porto Alegre
Lead sponsor
Leonhardt Ventures LLC
Collaborator