This was a non-inferiority randomized controlled trial designed to compare the efficacy and safety of cold versus hot snare polypectomy for the removal of 4-10 mm pedunculated colorectal polyps. The primary outcome was delayed postpolypectomy bleeding. The secondary outcomes included immediate postpolypectomy bleeding, procedure time, en bloc resection, complete histologic resection, use of haemostatic clips and perforation rate.
18-80 years old, male and female
Proposed colonoscopy and colonoscopy detection of at least one 4-10 mm pedunculated colorectal polyp
Contraindication to colonoscopy or polypectomy
Use of antiplatelet or anticoagulant drugs within 1 week before polypectomy
Alarming signs and symptoms of colorectal cancer (blood in stool, black stool, unexplained anaemia and weight loss, abdominal mass, positive rectal examination; or imaging and laboratory tests highly suspicious for colorectal cancer) or endoscopic manifestations of polyps highly suspicious for high-grade intraepithelial neoplasia or carcinoma
Comorbidity with inflammatory bowel disease, colonic polyposis, or active gastrointestinal bleeding