Due to the increasing number and prolonged survival of malignant tumor patients treated with radiotherapy, the complication, such as acute radiation-induced intestinal injury, has become increasingly significant. Glucocorticoids may play a therapeutic role by regulating the inflammatory response in patients with acute radiation-induced intestinal injury. However, the conclusions of related studies were controversial.
Grade II-III acute radiation-induced rectosigmoid injury
Signed informed consents
Age ≥18 years
Rstimated survival time >1 year
Absolute contraindications to glucocorticoids
A history of glucocorticoids treatment within 3 months
Inflammatory bowel disease or infectious intestinal disease
Recurrence of malignant tumor