Efficacy and Safety of Triple-targeted Drug Therapy in Treatment-naive Patients With Non-low-risk PAH: A Real-world, Multicenter Study

Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18-80
SponsorQianfoshan Hospital

About this trial

This study is a multicenter, prospective, observational study aimed at investigating the efficacy and safety of triple targeted drug therapy in patients with arterial pulmonary hypertension (PAH) who are not at low risk and are receiving initial treatment. The prognosis of arterial pulmonary hypertension is explored.

Eligibility criteria

Qualifiers

Consent and sign the informed consent form

Non-low-risk PAH treatment-naive patients

Disqualifiers

Positive acute vascular response test for idiopathic/hereditary/drug-related arterial pulmonary hypertension

Pulmonary veno-occlusive disease/pulmonary capillary hemangiomatosis (PVOD/PCH) with arterial pulmonary

Pregnant or lactating women

Suffering from mental illness or cognitive impairment

Trial design

Treatments tested in this trial

  • Endothelin receptor antagonist (ERA) combined with PDE5i/sGC agonist dual therapy prostacyclin drugs

Treatment groups

48 Participants
are divided into 1 treatment group

Sponsors and collaborators

Qianfoshan Hospital

Lead sponsor

Chinese Academy of Medical Sciences, Fuwai Hospital

Collaborator

Jianghan University Affiliated Hospital

Collaborator