Efficacy in Preventing Hypertrophic Scars: A Randomised Controlled Trial Comparing Chitosan Cream, Silicone Gel & Olive Oil

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-65
SponsorUniversiti Sains Malaysia

About this trial

The goal of this clinical trial is to compare the efficacy of three different topical applications in preventing hypertrophic scars in adults with scars healed after suturing. The main question it aims to answer is: Is Chitosan cream effective in preventing hypertrophic scars?

Researchers will compare Chitosan cream with silicone gel and olive oil to see if there is any difference in their efficacies.

Participants will be randomly assigned to three groups, with each group using a different topical application. They will be instructed to:

* apply the topical application on their scar twice a day for 8 weeks * attend follow-up visits at 4, 12 and 24 weeks for a doctor to assess their scar and take clinical photographs * immediately inform the researcher if they experience any side effects

Eligibility criteria

Qualifiers

Patients with traumatic or surgical wounds which have healed by primary intention within 14 days

Length of scar at least 3cm

Disqualifiers

Patients with seafood allergy

Patients with scar from wounds that were complicated by infection or wound breakdown

Patients who have undergone scar treatment by other modalities

Patients with history of keloids / hypertrophic scars

Trial design

Treatments tested in this trial

  • Chitosan cream
  • Silicone Gel
  • Olive Oil Topical Oil

Treatment groups

120 Participants
are divided into 3 treatment groups

Sponsors and collaborators