Treatment of supraosseous defects (SD) may be challenging due to their limited regenerative potential. When located in aesthetic areas, treatment may result in a gingival recession increase with consequent patients' concerns in terms of aesthetic or tooth sensibility. In the present study, a minimally-invasive surgical procedure (namely, the Single Flap Approach, SFA) will be combined with the application of a viscoelastic gel containing polynucleotides and hyaluronic acid that was reported to positively modulate periodontal wound healing. The outcomes, evaluated 6 months after treatment, will be compared to those obtained with SFA alone. The evaluated outcomes will be either clinical (evaluation of clinical parameters such as gingival recession, residual probing depth, clinical attachment gain) or related to patient's perception (such as evaluation of the aesthetic or tooth sensibility).
age≥ 18 years;
diagnosis of Stage III or IV periodontitis22;
good physical status (ASA1 and ASA2 according to Physical Status Classification System);
systemic and local conditions compatible with periodontal surgical procedures;
poorly controlled diabetes (HbA1C ≥ 7%);
history of radiation therapy in the head and neck area;
history of chemotherapy;
systemic disease or conditions with a documented effect on bone metabolism and/or periodontal status/healing;