Efficacy of Bee Venom Phonophoresis in Treating Chronic Sinusitis:
Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-65
SponsorSinai University
About this trial
This double-blind, randomized controlled trial (BEE-SONIC) aims to evaluate the efficacy of bee venom phonophoresis in the treatment of chronic sinusitis. Thirty adult patients (aged 18-65 years) with clinically diagnosed chronic or acute sinusitis will be randomized into two groups: the intervention group will receive bee venom phonophoresis using low-to-moderate intensity ultrasound, while the control group will receive standard care consisting of oral decongestants and saline nasal irrigation. Primary outcomes include improvement in symptom severity (SNOT-22, Visual Analog Scale) and quality of life (SF-33). Secondary outcomes include reduction in facial pain, nasal congestion, and patient satisfaction. Data will be collected at baseline, midpoint, and post-intervention, and analyzed using paired t-tests and ANOVA. The study has received ethics approval from Sinai University's Human Research Ethics Committee, and informed consent will be obtained from all participants.
Eligibility criteria
Qualifiers
Adults aged 18 to 65 years.
Clinical diagnosis of chronic sinusitis (symptoms ≥ 12 weeks) or acute sinusitis confirmed by an otolaryngologist.
Willing and able to provide written informed consent.
Disqualifiers
Known allergy or hypersensitivity to bee venom or bee products.
Skin conditions (e.g., eczema, dermatitis, open wounds) over the area of ultrasound application.
Severe comorbid medical conditions (e.g., uncontrolled asthma, autoimmune disease, malignancy).
Pregnancy or breastfeeding.
Trial design
Treatments tested in this trial
- Bee Venom Phonophoresis
- Standard Care (oral decongestants + saline nasal irrigation)
- Bee Venom Phonophoresis
Treatment groups
30 Participants
are divided into 2 treatment groupsSponsors and collaborators
Source ClinicalTrials.gov