Efficacy of Gamma Auditory Stimulation for Cognitive Decline in Older Adults (Study 1)
Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age60+
SponsorChang Gung Memorial Hospital
About this trial
Animal studies have shown that 40 Hz auditory stimulation alone can improve spatial memory and reduce Aβ deposition. However, human studies using 40 Hz auditory stimulation alone remain limited. Therefore, this study will use a randomized, double-blind, placebo-controlled design to investigate the effects of 40 Hz auditory stimulation on cognitive function, EEG activity, sleep quality, and quality of life in older adults with mild cognitive impairment (MCI) or mild dementia.
Eligibility criteria
Qualifiers
Age over 60 years old.
MMSE≤ 24
CDR scores of 0.5 and 1
Voluntary to sign the Informed Consent Form.
Disqualifiers
Diagnosis of other psychiatric or neurological disorders
Drug or alcohol addictions.
Serious heart, liver or kidney disorders, and visual, auditory or motor impairments interfering with neuropsychological tests.
History of clinical stroke, major depressive disorder or dysthymic disorder according to the DSM-5.
Trial design
Treatments tested in this trial
- Gamma auditory stimulation device (active setting)
- Gamma auditory stimulation device (sham setting)
Treatment groups
70 Participants
are divided into 2 treatment groupsSponsors and collaborators
Source ClinicalTrials.gov