Efficacy of Stromal Vascular Fraction on Acne Scar Correction
Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age19-45
SponsorSeoul National University Hospital
About this trial
This study aims to evaluate the efficacy and safety of intradermal injection of autologous stromal vascular fraction (SVF) in the treatment of atrophic acne scars. SVF is a heterogeneous cell population derived from adipose tissue, containing various regenerative and immunomodulatory cells, including mesenchymal stem cells, endothelial progenitor cells, and pericytes.
In this prospective, randomized, split-face clinical trial, participants with atrophic acne scars will receive SVF injections on one side of the face and normal saline (NS) injections on the contralateral side as a control. Clinical efficacy will be assessed through blinded scar counts, digital imaging, and histological evaluations including epidermal and dermal regenerative markers. The study is designed to investigate whether SVF provides superior clinical improvement compared to placebo.
Eligibility criteria
Qualifiers
Age between 19 and 45 years
Presence of bilateral atrophic acne scars (boxcar, rolling, or icepick types) on the face
Willingness to undergo fat harvesting procedure
Ability to comply with study visits and follow-up
Disqualifiers
Active acne lesions on the treatment area
History of keloid or hypertrophic scarring
Prior treatment for acne scars (e.g., laser, filler, microneedling) within the past 6 months
History of systemic immunosuppressive therapy within the past 3 months
Trial design
Treatments tested in this trial
- stromal vascular fraction (SVF)
- Normal Saline (NS)
Treatment groups
16 Participants
are divided into 2 treatment groupsLocations
Sponsors and collaborators
Source ClinicalTrials.gov