About this trial
Chronic pain is a common complication after cardiothoracic surgery. The prevalence of post-sternoyomy pain syndrome (PSPS) ranges from 33% to 91%. Exact pathogenetic mechanisms for developing chronic pain after sternotomy are unknown. Apart from intraoperative nerve damage and subsequent postoperative neuropathic pain, operation techniques, age, sex, pre-existing pain, genetic and psychosocial factors, severe postoperative pain, and analgesic management are suspected to have an impact on the development of PSPS .
Eligibility criteria
This trial accepts healthy volunteersQualifiers
age between 18 and 75 years.
patient scheduled to undergo elective on-pump cardiac surgery with sternotomy.
American Society of Anesthesiologists classification of physical status < IV.
Disqualifiers
emergency surgery.
off-pump surgery.
redo surgery.
ejection fraction less than 35%.
Trial design
Parallel
Treatments tested in this trial
pecto intercostal fascial block using bupivacaine 0.25%
Procedure/Surgerypatients will receive bilateral ultrasound-guided pecto-intercostal fascial block using 20 ml of bupivacaine 0.25% for each side.
lidocaine infusion
Drug1.5 mg/kg lidocaine will be administered after induction of anesthesia, then 2mg/kg/h lidocaine will be administered with continuous intravenous infusion until the end of the surgery.
Treatment groups
Trial outcomes
Primary outcomes
Total dose of morphine in the first 24 h postoperatively.
total morphine consumed in the first 24 hour
Secondary outcomes
NRS numerical rating scale.
NRS ranging from grade 0 (no pain) to grade 10 (most severe pain) NRS\< 4 is acceptable for pain relief
chronic postoperative pain in 3 months after operation according to numerical rating scale
NRS ranging from grade 0 (no pain) to grade 10 (most severe pain) NRS\< 4 is acceptable for pain relief
Time to rescue analgesic
time from extubation to the time the patiants given analgesia
time to extubation
from end of surgery to the time of extubation
Sponsors and contacts
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