EIT-Guided Respiratory Physiotherapy for Prolonged Mechanical Ventilation (PMV)
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorCapital Medical University
About this trial
Patients with prolonged mechanical ventilation (PMV) frequently experience impaired ventilation distribution, respiratory muscle dysfunction, secretion retention, and delayed liberation from mechanical ventilation. Electrical impedance tomography (EIT) provides real-time bedside visualization of regional ventilation and enables individualized respiratory physiotherapy strategies.
This multicenter randomized controlled trial aims to evaluate whether EIT-guided respiratory physiotherapy improves ventilator-free days at day 28 compared with conventional respiratory physiotherapy in adult patients with PMV.
Respiratory physiotherapy consists of airway clearance, chest physiotherapy techniques, breathing pattern optimization, and therapeutic positioning. In the EIT-guided group, real-time EIT imaging is used to individualize physiotherapy strategies based on predefined ventilation distribution indicators, while the control group receives standardized physiotherapy according to institutional protocols without EIT guidance.
Secondary outcomes include successful liberation from mechanical ventilation, diaphragm ultrasound parameters, EIT-derived ventilation distribution indices (exploratory mechanistic outcomes), ICU Mobility Scale, healthcare resource utilization, and safety outcomes.
Eligibility criteria
Qualifiers
Age ≥ 18 years.
Invasive mechanical ventilation for ≥ 21 consecutive days.
Clinically stable and eligible for respiratory physiotherapy as determined by the treating team.
Expected to remain on invasive mechanical ventilation for at least 48 hours after enrollment.
Disqualifiers
Contraindications to electrical impedance tomography .
Hemodynamic instability requiring high-dose vasoactive support.
Severe hypoxemia refractory to optimization.
Unstable fractures or other contraindications to mobilization or positioning.
Trial design
Treatments tested in this trial
- EIT-Guided Respiratory Physiotherapy
- Conventional Respiratory Physiotherapy
Treatment groups
200 Participants
are divided into 2 treatment groupsSponsors and collaborators
Source ClinicalTrials.gov