Electro-acupuncture to Treat Disorder of Consciousness
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorThe Second Affiliated Hospital, Guangzhou University of Traditional Chinese Medicine
About this trial
With the rapid development of life support technology, more and more people can survive severe brain injury. Some survivors regain consciousness after a period of coma, however, many patients develop prolonged disorders of consciousness (DOC), which poses a therapeutic challenge for clinicians and a heavy burden for their families. The investigators design an Electro-acupuncture to treat disorder of consciousness (AcuDoc) trial with the aim of validating the clinical effect of electroacupuncture in treating DOC and exploring its therapeutic mechanisms by integrating EEG, neuroimaging, evoked potential tests, and behavioral assessments.
Eligibility criteria
Qualifiers
Age ≥ 18 years;
With cerebral damage due to TBI；
Diagnosed with UWS or MCS based on at least two CRS-R assessments;
From 4 to 16 weeks from the onset of brain injury;
Disqualifiers
With a history of neurological or psychiatric disorder prior to the brain injury;
With uncontrolled seizures or status epilepticus;
Unstable vital signs and requiring the use of vasoactive agents;
With the use of general anesthetics or central acting sedative;
Trial design
Treatments tested in this trial
- Electroacupuncture
- Sham electroacupuncture
Treatment groups
50 Participants
are divided into 2 treatment groupsSponsors and collaborators
Source ClinicalTrials.gov