Electroanatomic Interactions Between Transcatheter Pulmonary Valve Prostheses and Anatomic Isthmuses in Repaired Tetralogy of Fallot

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
AgeNot listed
SponsorBoston Children's Hospital

About this trial

Individuals with repaired Tetralogy of Fallot (rTOF) remain at risk for sudden cardiac death from ventricular tachycardia (VT). Transcatheter pulmonary valve replacement (TPVR) indications continue to broaden, yet its capability to reduce the risk of VT and sudden cardiac death remains unknown. Thus, in a cohort of participants with rTOF who are presenting for TPVR the investigators intend to: (1) quantify and localize right ventricular (RV) isthmuses with abnormal voltage and/or conduction velocity; (2) identify which RV isthmuses are at risk of being "jailed" by TPV prostheses; and (3) explore the feasibility of omnipolar technology to characterize wavefront directionality and differentiate slow conduction from conduction block.

Eligibility criteria

Qualifiers

Diagnosis of tetralogy of Fallot (TOF) or double outlet right ventricle (DORV)

Referred for transcatheter pulmonary valve replacement (TPVR) per routine clinical indications

Weight >=25 kg

Disqualifiers

None

Trial design

Treatments tested in this trial

  • Electroanatomic substrate mapping

Treatment groups

60 Participants
are divided into 1 treatment group

Sponsors and collaborators