Electroencephalogram in Patients With Friedreich's Ataxia for the Study of the Structural and Functional Connectome.
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age8-60
SponsorIRCCS Eugenio Medea
About this trial
Prospective, exploratory, multicenter pilot study investigating the structural and functional connectome in patients with Friedreich's Ataxia (FRDA) using high-density electroencephalogram (HD-EEG). The aim is to identify neurophysiological biomarkers and analyze the relationship between cortical connectivity, cognitive functioning, and clinical severity, particularly in response to rehabilitation treatment.
Eligibility criteria
Qualifiers
age between 8 and 60 years;
genetic diagnosis of FRDA: presence of guanine-adenine trinucleotide (GAA) expansion in the two alleles of the fratassin gene, GAA1 and GAA2;
score on the Scale for the Assessment and Rating of Ataxia (SARA) < 30;
ability to take part in a neuropsychological assessment in Italian.
Disqualifiers
age different from the range 8-60 years;
diagnosis of acquired ataxia or other genetic ataxias;
SARA scale score ≥ 30;
inability to take part in an Italian-language neuropsychological assessment
Trial design
Treatments tested in this trial
- HD-EEG recordings, combined with cognitive and motor assessment
Treatment groups
30 Participants
are divided into 1 treatment groupSponsors and collaborators
Source ClinicalTrials.gov