Electrolyte Beverage Combined With Polyethylene Glycol for Colonoscopy Bowel Preparation

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-75
SponsorNanfang Hospital, Southern Medical University

About this trial

This randomized controlled trial aims to evaluate the effects of different ratios of electrolyte beverage and water combined with polyethylene glycol (PEG) on bowel preparation quality before colonoscopy. Participants undergoing elective colonoscopy will be randomly assigned to one of three bowel preparation regimens: PEG prepared with water only, PEG prepared with a low ratio of electrolyte beverage and water, or PEG prepared with a medium ratio of electrolyte beverage and water. The primary outcome is adequate bowel preparation assessed by the Boston Bowel Preparation Scale (BBPS). Secondary outcomes include bowel preparation completion rate, tolerability, adverse events, repeat colonoscopy rate, adenoma detection rate, and ingestion rhythm characteristics during bowel preparation. This study also aims to explore whether electrolyte beverage-assisted bowel preparation may improve bowel cleansing quality by influencing participants' ingestion rhythm and adherence during PEG intake.

Eligibility criteria

Qualifiers

Adults aged 18-75 years scheduled to undergo elective colonoscopy

Meet the standard clinical indications for colonoscopy;

Able to understand and comply with the bowel preparation procedure and complete oral polyethylene glycol (PEG) intake as required;

Able to comply with study-related data collection and follow-up;

Disqualifiers

Previously diagnosed colorectal cancer, intestinal obstruction, or suspected intestinal obstruction;

Active gastrointestinal bleeding or a definite history of gastrointestinal bleeding within the past 4 weeks (including melena, hematochezia, or hematemesis);

Severe renal insufficiency, decompensated heart failure, significant electrolyte imbalance, or other conditions unsuitable for PEG bowel preparation;

Known allergy to polyethylene glycol or components of the electrolyte beverage used in the study;

Trial design

Treatments tested in this trial

  • PEG With Water
  • PEG With Low-dose Electrolyte Beverage
  • PEG With Medium-dose Electrolyte Beverage

Treatment groups

405 Participants
are divided into 3 treatment groups