En Bloc Resection Versus Separation Surgery Combined With Radiotherapy for the Treatment of Spinal Oligometastatic Tumor.

Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18-75
SponsorShanghai Changzheng Hospital

About this trial

The purpose of this clinical trial is to explore the impact of En bloc surgery and separation surgery combined with radiation therapy on the prognosis and survival of patients with spinal oligometastatic cancer, describe the clinical results, and optimize future treatment goals

Eligibility criteria

Qualifiers

1) Be able to sign written informed consent.

2) Age range from 18 to 75 years old, regardless of gender.

3) Within conservative treatment, the patient still has uncontrollable pain, metastatic cancer lesions that still progress, spinal instability/potential instability, or symptoms of spinal cord/nerve compression.

4) After the patient underwent Positron Emission Tomography-Computed Tomography (PET-CT) examination, it was indicated that there were no more than 3 metastatic organs and no more than 5 metastatic lesions in the whole body of cancer. Among them, there was at least 1 spinal metastasis and at most 5 spinal metastases.

Disqualifiers

1) Primary tumors of the spine or multiple tumors of the body, with>3 metastatic organs and>5 metastatic sites.

2) Previously underwent spinal surgery, or received radiotherapy for the responsible segment of this treatment.

3) Severe heart, lung, liver, kidney or other diseases affecting the surgery.

4) Having cognitive impairment, sensory aphasia, and inability to understand basic instructions.

Trial design

Treatments tested in this trial

  • total en bloc spondylectomy

Treatment groups

182 Participants
are divided into 2 treatment groups

Sponsors and collaborators

Shanghai Changzheng Hospital

Lead sponsor

Peking University Third Hospital

Collaborator

Peking University People's Hospital

Collaborator

Henan Cancer Hospital

Collaborator

First Affiliated Hospital, Sun Yat-Sen University

Collaborator

Sun Yat-sen University

Collaborator

Zhejiang University

Collaborator

Tianjin Hospital

Collaborator

The First Affiliated Hospital of Nanchang University

Collaborator

The Third Affiliated Hospital of Southern Medical University

Collaborator