About this trial
The purpose of this clinical trial is to explore the impact of En bloc surgery and separation surgery combined with radiation therapy on the prognosis and survival of patients with spinal oligometastatic cancer, describe the clinical results, and optimize future treatment goals
Eligibility criteria
Qualifiers
1) Be able to sign written informed consent.
2) Age range from 18 to 75 years old, regardless of gender.
3) Within conservative treatment, the patient still has uncontrollable pain, metastatic cancer lesions that still progress, spinal instability/potential instability, or symptoms of spinal cord/nerve compression.
4) After the patient underwent Positron Emission Tomography-Computed Tomography (PET-CT) examination, it was indicated that there were no more than 3 metastatic organs and no more than 5 metastatic lesions in the whole body of cancer. Among them, there was at least 1 spinal metastasis and at most 5 spinal metastases.
Disqualifiers
1) Primary tumors of the spine or multiple tumors of the body, with>3 metastatic organs and>5 metastatic sites.
2) Previously underwent spinal surgery, or received radiotherapy for the responsible segment of this treatment.
3) Severe heart, lung, liver, kidney or other diseases affecting the surgery.
4) Having cognitive impairment, sensory aphasia, and inability to understand basic instructions.
Trial design
Treatments tested in this trial
- total en bloc spondylectomy
Treatment groups
Sponsors and collaborators
Shanghai Changzheng Hospital
Lead sponsor
Peking University Third Hospital
Collaborator
Peking University People's Hospital
Collaborator
Henan Cancer Hospital
Collaborator
First Affiliated Hospital, Sun Yat-Sen University
Collaborator
Sun Yat-sen University
Collaborator
Zhejiang University
Collaborator
Tianjin Hospital
Collaborator
The First Affiliated Hospital of Nanchang University
Collaborator
The Third Affiliated Hospital of Southern Medical University
Collaborator