Endogenous Energy Production in Critically Ill Patients
Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorKarolinska University Hospital
About this trial
The aim of this study is to investigate when critically ill patients transition from a non-suppressible catabolism to a normal response to feeding.
Endogenous production of glucose, fat and protein will be studied on a minimum of two occasions in mechanically ventilated ICU patients, in a fasted state and during parenteral nutrition. Substrate kinetics are estimated by a tracer dilution method using infusions of isotopically labeled glucose, glycerol and phenylalanine. Blood sampling for metabolomics analysis will be performed to elucidate potential biomarkers indicating an anabolic response to nutrition.
Eligibility criteria
Qualifiers
≥18 years old and admitted to the ICU
Invasive mechanical ventilation
Arterial and central line in situ
Expected to remain in ICU >72 hours
Disqualifiers
Lack of informed consent by patient/next of kin
Liver transplant
Acute or acute on chronic liver failure
Cirrhosis
Trial design
Treatments tested in this trial
- Stable isotope tracers
- Parenteral nutrition
Treatment groups
40 Participants
are divided into 2 treatment groupsSponsors and collaborators
Source ClinicalTrials.gov