Endoscopic Third Ventriculostomy vs. Ventriculoperitoneal Shunt in Idiopathic Normal Pressure Hydrocephalus (ENDOVEST)

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age40+
SponsorUniversity Hospital, Basel, Switzerland

About this trial

The aim of this single-center, two-arm, open-labeled, randomized controlled clinical study is to compare two surgical interventions, endoscopic third ventriculostomy and ventriculoperitoneal shunt, in treating idiopathic normal pressure hydrocephalus in terms of clinical improvement.

Eligibility criteria

Qualifiers

>40 years of age

Symptom duration ≥3 months, <24 months

No antecedent head trauma, ICH, meningitis, or other cause of secondary hydrocephalus

MUST show gait/balance disturbance, PLUS cognition impairment AND/OR urinary dysfunction.

Disqualifiers

≤40 years of age

No informed consent

Other neurologic, psychiatric or general medical condition which is sufficient to explain the presenting symptoms.

Previous cranial neurosurgical interventions

Trial design

Treatments tested in this trial

  • Endoscopic third ventriculostomy (ETV)
  • Ventriculoperitoneal shunt (VPS)

Treatment groups

150 Participants
are divided into 2 treatment groups