Endothelial Dysfunction After SCI
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorCraig Hospital
About this trial
This study plans to learn how endothelial cells, single cell lining of blood vessels may be dysfunctional after a spinal cord injury. Endothelial dysfunction will be measured by the capacity of blood vessels to vasodilate (increase in size) and alter blood flow is lower in adults with a spinal cord injury in comparison to adults without a spinal cord injury. The mechanisms which may alter this function may be critical in reducing the risk of heart attacks and strokes in people with spinal cord injuries.
Eligibility criteria
Qualifiers
Chronic (>12 months) SCI
Motor complete (AIS A/B) SCI
Paraplegia (neurological level of injury [NLI] at T2 or below)
Disqualifiers
Overt chronic diseases as assessed by: a) clinically documented medical history; b) physical examination; c) blood pressure and ECG at rest; and d) complete blood chemistries and hematological evaluation.
Active infection
Recent (< 3 months) surgery
Current smoking history (within past 12 months)
Trial design
Treatments tested in this trial
- Intra-arterial Infusion of Vasoactive Agents
- Intra-arterial Vitamin C Infusion
- Blood Sampling
Treatment groups
40 Participants
are divided into 2 treatment groupsSponsors and collaborators
Craig Hospital
Lead sponsor
University of Colorado, Boulder
Collaborator
Denver Health and Hospital Authority
Collaborator
Source ClinicalTrials.gov