Comparison of the efficacy and safety of endovascular treatment versus medical treatment in patients with chronic intracranial artery occlusion.
Age ≥18 years
Occlusion of the unilateral middle cerebral artery, basilar artery, intracranial internal carotid artery, or vertebral artery, as confirmed by computed tomography angiography (CTA), magnetic resonance angiography (MRA), or digital subtraction angiography (DSA)
Modified Rankin Scale (mRS) score of 0-2
Presence of symptoms related to the occluded vessel, as determined by the physician, with the most recent symptom onset occurring more than 4 weeks and within 6 months prior to enrolment
Evidence of hemorrhage on CT or MRI
Large hemispheric infarction involving >50% of the middle cerebral artery territory on CT or MRI
Severe pre-stroke disability (modified Rankin Scale score ≥2) or life expectancy <12 months
Major comorbidities that may interfere with outcome assessment and follow-up (e.g., severe heart failure, renal failure, etc.)