About this trial
Aphasia is an acquired impairment of language, that commonly results from damage to language areas in the brain (typically the left side of the brain). This impairment is seen in many aspects of language, including understanding, speaking, reading and writing. It is estimated that about 2 million individuals are currently living with aphasia in the United States. Further, about 200,000 Americans acquire aphasia every year (National Aphasia Association, 2020). Aphasia poses significant impact on the affected individuals and their families. Behavioral treatments that target language deficits have been shown to enhance overall communication skills and life satisfaction among individuals with aphasia. Although there is evidence that suggests that treatment is efficacious for individuals with aphasia, the extent of improvement long-term coupled with the neural patterns among those individuals are largely unknown. The current study aims to investigate the efficacy of language-based treatment and its corresponding neural patterns.
Eligibility criteria
Qualifiers
Present with speech-language impairment (aphasia) caused by stroke or dementia
A medical diagnosis of primary progressive aphasia (PPA) by a neurologist or physician
Are native speakers of English
Present with no contraindications for MRI
Disqualifiers
Individuals diagnosed with mood, anxiety, psychotic or substance abuse disorders.
Individuals with highly magnetizable metallic implants, including certain dental work, may be excluded due to image quality in MRI.
Individuals with other neurological disorders besides the ones of interest for the study (e.g., epilepsy, Multiple Sclerosis, Parkinson's Disease)
Individuals with contraindications for MRI. This includes but is not limited to pacemakers, metallic cardiac pumps, valves, magnetic materials such as surgical clips, implanted electronic perfusion pumps, or any other condition that would preclude proximity to a strong magnetic field.
Trial design
Treatments tested in this trial
- individualized speech-language training
- standard language intervention