Meningiomas are the most common primary intracranial tumors. Current treatment relies on surgical resection and radiotherapy, but molecular predictors for recurrence are lacking. This study aims to investigate epigenetic features, specifically histone post-translational modifications (PTMs) and DNA methylation, to stratify patients. The study involves a retrospective cohort to define an epigenetic signature and a prospective cohort to validate it in tissues and liquid biopsies (plasma/EVs).
Patient aged 18 years or older.
First diagnosis of uni-focal meningioma of the convexity.
Macroscopical total resection (Simpson 1-3).
Surgery performed between 2007 and 2016;
Genetic syndromes.
Diffuse Meningeal Meningiomatosis.
Patients who underwent experimental treatment in neo-adjuvant setting.
Previous surgical/medical treatment for another meningioma;
Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta
Lead sponsor
University of Milan
Collaborator
Università degli Studi del Piemonte Orientale Amedeo Avogadro
Collaborator