Erector Spinae Plane Block Improves Organ Dysfunction in Septic Patients With Acute Gastrointestinal Injury
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorJing Cai, MD
About this trial
This study is a prospective, multicenter, parallel-group, open-label, randomized controlled clinical trial. Sepsis is defined as organ dysfunction induced by infections. And sepsis and gastrointestinal injury can be the leading cause for each other. Our previous study showed erector spinae plane block improved the organ dysfunctions in patients with AGI. The aim of the clinical trial is to investigate erector pinae plane block improves the organ dysfunction in septic patients with acute gastrointestinal injury.
Eligibility criteria
Qualifiers
Septic patients with acute gastrointestinal injury grade II or III;
Age over 18 years;
Expected to stay in the ICU for at least 3 days or longer;
Disqualifiers
Mean arterial pressure less than 65 mmHg after fluid resuscitation, or requirement for an intravenous norepinephrine dose of greater than 0.5 µg/kg/min to maintain a normal mean arterial pressure;
Heart rates less than 50 beats/min, or concomitant with moderate-to-severe atrioventricular block without a pacemaker;
Contraindications for erector spinae plane blocks, including infection of the puncture site, spinal diseases or immobilization;
Primary gastrointestinal disorders requiring a surgical procedure, such as mechanical intestinal obstruction, massive gastrointestinal hemorrhage, and gastrointestinal perforation;
Trial design
Treatments tested in this trial
- Erector spinae plane block
Treatment groups
116 Participants
are divided into 2 treatment groupsSponsors and collaborators
Jing Cai, MD
Lead sponsor
Zhujiang Hospital
Sponsor institution
Zhongshan People's Hospital, Guangdong, China
Collaborator
Zhongshan Hospital Of Traditional Chinese Medicine
Collaborator
Source ClinicalTrials.gov