ESD for Colorectal LSL Using a Selective Strategy - a Prospective Cohort Study
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorWestern Sydney Local Health District
About this trial
Colonic Laterally spreading lesions (LSL) =\> 20mm are at high risk to progress to cancer. Overt stigmata of submucosal invasive cancer (SMIC) has been well characterized and includes ulceration and surface pit pattern changes as per the Kudo classification of type V.
In a recent report, risk factors for LSL with SMIC and no overt stigmata (i.e. covert SMIC) were described. Resection of these lesions 'en-bloc' can allow for better histological staging and potentially reduce the need for surgical resection.
Eligibility criteria
Qualifiers
All patients referred for colorectal resection of large laterally spreading lesions in colon.
Can give informed consent to trial participation
Disqualifiers
Previous resection or attempted resection of target adenoma lesion
Endoscopic appearance of invasive malignancy
Age less than 18 years
Pregnancy
Trial design
Treatments tested in this trial
- Endoscopic Submucosal Dissection
- Endoscopic Mucosal Resection
Treatment groups
391 Participants
are divided into 2 treatment groupsSponsors and collaborators
Source ClinicalTrials.gov