Esketamine Combined With Remimazolam on Postoperative Sleep Disturbance and Anxiety in Patients

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age20-65
SponsorTianjin Medical University General Hospital

About this trial

To explore the effects of esketamine combined with remimazolam on postoperative sleep disturbance and anxiety in surgical patients undergoing gastroenteroscopies

Eligibility criteria

Qualifiers

Age 20-65 years old;

ASA classification is grade I-III;

Elective surgery is proposed

BMI of 19-30 kg/m2;

Disqualifiers

Those who are known to be allergic to the drug ingredients in this study and their allergic constitution;

Allergic history of general anesthesia drugs, opioid drugs, non-steroidal drugs;

History of neurological diseases; History of chronic pain; Drug and alcohol addiction; A long history of opioid use; Opiates were given 48 hours before surgery;

ASA rating of IV or V;

Trial design

Treatments tested in this trial

  • Esketamine
  • Remimazolam
  • Esketamine and remimazolam
  • normal saline

Treatment groups

400 Participants
are divided into 4 treatment groups