Patients with IgE mediated food Allergy have elevated risk of eosinophilic esophagitis, and new therapies like oral immunotherapy (OIT) carry additional risk of Eosinophilic Esophagitis (EoE). The goal of this study is to investigate the Esophageal String Test (EST) as a screening tool for Eosinophilic Esophagitis (EoE) during OIT therapy. Investigators will compare the efficacy of the Esophageal String Test to symptom assessment using a validated patient reported symptom questionnaire, the Pediatric Eosinophilic Esophagitis Symptom Score (PEESS) v2.0. Investigators will utilize these tools to screen patients at their baseline visit prior to the start of OIT, then at the 3- and 6-month OIT follow-up visits.
Male or female, aged 7 to 18 years old, inclusive
Have a history of Immunoglobulin (IgE)-mediated food allergy
Considering using oral immunotherapy (OIT) for food allergies at CHOP°
Able & willing to swallow the esophageal capsule
Known or expected need for MRI imaging during the study period
Known connective tissue disease
Known eosinophilic disorder including any eosinophilic gastrointestinal disorder and hypereosinophilic disorder
Past history of caustic ingestion or other esophageal injury