Patients with monoclonal gammopathies either benign or malignant may develop inflammatory symptoms such as Schnitzler syndrome. We proposed to name those cases as monoclonal gammopathy of inflammatory significance, or MGIS.
The aim of the study is to search for inflammatory pathway that may be activated in case MGIS and to search if the genetic of tumoral cell could explain those activations.
Patient over 18 years of age with the capacity to give express free and informed consent.
Patient followed in one of the services participating in the study and meeting the 2 following conditions
have myelodysplastic syndrome, or multiple myeloma, or monoclonal gammopathy of undetermined significance, or Schnitzler's syndrome.
have a fever of undetermined etiology associated with one of the following symptoms: rash, arthralgia or arthritis, serositis, abdominal pain.
Patient incapable of giving express free and informed consent.
Subject under guardianship, curatorship or safeguarding of justice.
Subject does not speak French.
Subject incapable of answering questions or expressing himself/herself.
Assistance Publique - Hôpitaux de Paris
Lead sponsor
INSERM UMR 1163
Collaborator