Establishment of the Chinese Preclinical Alzheimer's Disease Study With Multiple Neuroimaging
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age45-90
SponsorHuashan Hospital
About this trial
The goal of this observational study is to investigate neuroimage and biomarkers in the Alzheimer's continuum in Chinese population. We aimed to:
* To reveal the progress of AD by multiple neuroimage and biomarkers; * To reveal the longitudinal change of biomarkers and cognition of AD in Chinese population; * To investigate the interaction of markers between body and brain; * To set up new markers by neuroimage.
Eligibility criteria
Qualifiers
Aged between 45 and 90 years; no gender restrictions;
CDR score ≥ 0.5;
MMSE score ≤ 24;
Brain MRI findings support the diagnosis of AD, with no evidence of other neurological diseases;
Disqualifiers
Presence of severe neurological diseases or serious disorders affecting the gastrointestinal, cardiovascular, hepatic, renal, hematologic, oncologic, endocrine, respiratory, or immune systems;
Presence of MRI-incompatible metal implants, including cardiac pacemakers, intravascular metal devices, insulin pumps, cochlear implants, nerve stimulators, or cerebral aneurysm clips;
Inability to tolerate MRI noise or a history of claustrophobia;
Exposure to ionizing radiation exceeding 50 mSv within the past year due to participation in other clinical or scientific research;
Trial design
Treatments tested in this trial
- No Intervention: Observational Cohort
Treatment groups
3,000 Participants
are divided into 1 treatment groupSponsors and collaborators
Source ClinicalTrials.gov