This multicenter observational cohort study aims to evaluate whether estimated first-trimester risk of preeclampsia (PE) is associated with subclinical atherosclerosis, cardiovascular risk profile, and cardiovascular events in women with type 1 diabetes (T1D) at least 3 years after pregnancy.
Women with T1D and at least one prior pregnancy with documented first-trimester PE screening will be classified as high or low PE risk according to validated multivariable algorithms. The presence of carotid plaques, cardiometabolic risk factors, and incident cardiovascular events will be assessed during a study visit.
Age ≥ 18 years
Confirmed diagnosis of type 1 diabetes
At least one prior pregnancy with first-trimester preeclampsia screening (<14 weeks gestation)
≥3 years since last pregnancy
Previous multiple pregnancy
Cardiovascular disease before pregnancy (coronary heart disease, stroke/TIA, peripheral artery disease, heart failure)
Active pregnancy at time of evaluation
Alcohol or substance dependence (except nicotine/caffeine) in the last 3 years
Institut d'Investigacions Biomèdiques August Pi i Sunyer
Lead sponsor
Hospital Mutua de Terrassa
Collaborator
Sociedad Española de Endocrinología y Nutrición
Collaborator