Estimation of P0.1 Using Ultrasound Indexes of Diaphragm Function
ConditionAcute Respiratory Disease
Trial statusNot yet recruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorAssistance Publique - Hôpitaux de Paris
About this trial
Occlusion pressure at 100 ms (P0.1) is a reliable and non-invasive index of inspiratory drive that can be measured easily on most ventilator. Unfortunately, P0.1 cannot be measured reliably in non-intubated patients. In those receiving non-invasive ventilation, the measurement of P0.1 might be inaccurate due to leaks. P0.1 cannot be measured at all in patients receiving high-flow nasal canulae (HFNC).
Ultrasound indices of diaphragm contractile function, namely diaphragm excursion, velocity and thickening fraction, could be reliable and non-invasive proxies of respiratory drive in non-intubated patient.
Our hypothesis is that ultrasound indices of diaphragm function may reliably estimate P0.1. To validate this hypothesis, theses indices will be measured simultaneously with P0.1 in intubated patients, during diaphragm loading conditions similar to spontaneous breathing: the spontaneous breathing trial (SBT). The SBT is used to evaluate if patients can breathe without the assistance provided by the ventilator, and thus, be weaned from mechanical ventilation.
Eligibility criteria
Qualifiers
- Age ≥ 18 years old
Patient intubated or tracheostomized
Decision by the clinician in charge to initiate a SBT
After information, the patient or next of kind did not refuse to participate (according to the French law, written informed consent is waived)
Disqualifiers
- Suspicion of diaphragmatic nerves injury
Preexisting neuromuscular disease
Spinal cord injury above C5
Neuromuscular blockade within last 24 hours
Trial design
Treatments tested in this trial
- Spontaneous breathing trial
Treatment groups
No treatment groups listed
Locations
Sponsors and collaborators
Source ClinicalTrials.gov