About this trial
the introduction of new MV modalities has shown promising results in reducing the incidence of weaning failure, mainly due to a more physiologic approach which allows respiratory muscle preservation. Among them, the Neurally Adjust Ventilatory Assist (NAVA) seemed to be associated with lower incidence of weaning failure and subsequent duration of mechanical ventilation, compared to standard modalities like the Pressure Support Ventilation (PSV) . Moreover, NAVA allows the evaluation of the diaphragm electrical activity (EAdi), an index of diaphragmatic neural respiratory drive. However, no study has compared TFic values during PSV and NAVA modalities in patients with difficult weaning from MV admitted in ICU.
Eligibility criteria
Qualifiers
patients who have failed at least one weaning attempt
mechanical ventilation for at least 24 hours
Disqualifiers
Pregnancy
Obesity (Body Mass Index > 35 kg/m2)
Contraindication to the insert of a nasogastric tube
Neuromuscular diseases
Trial design
Treatments tested in this trial
- difficult weaning patients