Etiologic Diagnosis Algorithm in Infective Endocarditis
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorI.M. Sechenov First Moscow State Medical University
About this trial
The goal of this study is to evaluate the impact of a diagnostic algorithm combining culture-based and molecular methods on the frequency of etiotropic antibiotic therapy prescription within 14 days of diagnosis of infective endocarditis
Eligibility criteria
Qualifiers
Informed consent,
Age ≥ 18,
IE (definite or possible per the 2023 Duke-International Society for Cardiovascular Infectious Diseases Criteria for Infective Endocarditis)
Disqualifiers
Pregnancy/breastfeeding
Unconfirmed or rejected IE diagnosis,
Very high risk of death within 14 days due to severe complications of the main or concomitant disease(s), according to the physician's opinion;
Prior use of antibiotic therapy (except documented treatment failure).
Trial design
Treatments tested in this trial
- Molecular tests (PCR, sequencing)
- Standard Clinical Practice
Treatment groups
128 Participants
are divided into 2 treatment groupsSponsors and collaborators
I.M. Sechenov First Moscow State Medical University
Lead sponsor
Federal State Budgetary Institution of the Central Research Institute of Epidemiology of Rospotrebnadzor
Collaborator
City Clinical Hospital Named After S. S. Yudin, Moscow, Russian Federation
Collaborator
City Clinical Hospital №67 Named After L. A. Vorokhobova, Moscow, Russian Federation
Collaborator
A.N. Bakulev National Medical Research Center for Cardiovascular Surgery of the Russian Ministry of Health, Moscow, Russian Federation
Collaborator
Source ClinicalTrials.gov