Etiological Study of Persistent Velopharyngeal Insufficiency in Children With Operated Velopalatine Cleft by Analysis of Velopharyngeal Motor Skills in Static and Dynamic MRI

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age7-12
SponsorCentre Hospitalier Universitaire, Amiens

About this trial

Velopharyngeal insufficiency is defined as the inability of the soft palate to isolate the nasopharynx from the oropharynx. It is a frequent sequela in patients with a velopalatine cleft despite anatomical restoration of the soft palate by intravelar veloplasty at 6 months. If rehabilitation by a speech therapist is not successful, a pharyngoplasty can be discussed. In the last ten years, MRI was used in dynamic and static way, to analyzed velopharyngeal muscles, in particular Levator Veli Palatini. MRI could be used to identify the etiology of VPI in those patients, and thus allow personalized rehabilitation and surgical management. The aim of this study is to examine the differences in velopharyngeal motricity as well as velar muscles morphology, positioning, and symmetry of children with repaired cleft palate with different degrees of severity of velopharyngeal insufficiency (VPI), and children with labial cleft (noncleft palate anatomy).

Eligibility criteria

Qualifiers

Children aged 7 to 12 years with Isolated cleft lip

isolated velopalatal cleft

Without a diagnosis of syndromic cleft or Pierre Robin sequence

French speaking, and French is the native language

Disqualifiers

Refusal of the parents and/or the patient

With a contraindication to MRI

Whose follow-up was initiated in another center and/or whose surgery was performed in another center

Whose surgical schedule has not been followed

Trial design

Treatments tested in this trial

  • real time MRI

Treatment groups

30 Participants
are divided into 4 treatment groups