European Association of Cardiovascular Imaging Multiple and Mixed Valvular Disease Study

ConditionsHeart Valve Diseases Multiple Valve Disease, Unspecified Aortic Valve Disease Aortic Valve Stenosis Aortic Valve Insufficiency Mitral Valve Disease Mitral Valve Stenosis Mitral Valve Insufficiency and Aortic Valve Insufficiency Mitral Valve Insufficiency Aortic Valve Stenosis With Insufficiency Mitral Valve Disease Mixed Tricuspid Valve Insufficiency Tricuspid Valve Disease Tricuspid Stenosis

Trial statusRecruiting

Trial phaseNot listed

Trial typeObservational

Biological sexAll

Age18+

SponsorAssistance Publique - Hôpitaux de Paris

About this trial

This study aims to investigate the prevalence and characteristics of multiple and mixed valvular heart disease (MMVD), which includes combinations of stenotic or regurgitant lesions on cardiac valves. The research will be conducted as a multicenter observational study, involving several centers worldwide, and will have a one-year follow-up period (with a possible extension to 5 years). The primary aim is to determine the proportion of MMVD among patients evaluated for valvular heart disease. Secondary aims include the evaluation of the epidemiologic distribution of clinical, biological, and cardiovascular imaging characteristics at baseline, management strategies, and their impact on prognosis. The study will also evaluate clinical outcomes such as mortality, hospitalization for heart failure, and changes in echocardiographic parameters. This research aims to provide valuable insights into the diagnosis, management, and prognosis of MMVD, addressing an important knowledge gap in this area.

Eligibility criteria

Qualifiers

Age ≥ 18 years

Patient referred to the cardiovascular imaging department.

Multiple VHD: at least 2 moderates to severe VHD involving ≥ 2 different valves, using the current ESC guidelines.

Mixed VHD: at least moderate stenosis and at least moderate regurgitation of a single valve, using the current ESC guidelines.

Disqualifiers

History of prior valve surgery or percutaneous valve intervention (concerning a valve other than those involved in the definition of MMVD).

Acute infective endocarditis at the time of evaluation for inclusion (confirmed according to modified Duke criteria) or history of endocarditis ≤ 6 months.

Complex congenital heart diseases.

Trial design

Treatments tested in this trial

Intervention not provided

Treatment groups

No treatment groups listed

Sponsors and collaborators

Assistance Publique - Hôpitaux de Paris

Lead sponsor

European Association of Cardiovascular Imaging

Collaborator

Source ClinicalTrials.gov