EUS-guided Response Assessment to NSBB
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-80
SponsorUniversitaire Ziekenhuizen KU Leuven
About this trial
The goal of this clinical trial is to learn if endoscopic ultrasound (EUS)-guided portal pressure measurement can determine the treatment response to non-selective beta-blockers (NSBB) in patients with cirrhosis and clinically significant portal hypertension (CSPH). Participants will undergo EUS-guided portal pressure measurement before start of Carvedilol en after three months of treatment. EUS-guided measurements will be paired with transjugular hepatic venous pressure gradient (HVPG) measurement as well as non-invasive tests for assessment of portal hypertension.
Eligibility criteria
Qualifiers
Patients with a clinical and/or pathological diagnosis of compensated cirrhosis.
Patients with suspicion of CSPH and thus indication for NSBB treatment.
Patients not yet on NSBB therapy.
Patients willing and able to undergo repeated HVPG and EUS-guided pressure measurements as per protocol.
Disqualifiers
Patient is <18 or >80 years of age
Patient is pregnant, breast-feeding or planning to become pregnant during the course of the study
Patient is unwilling or unable to sign the informed consent
Patients in whom general anesthesia or endoscopic procedures are contraindicated Medical criteria
Trial design
Treatments tested in this trial
- endoscopic ultrasound-guided portal pressure measurement
Treatment groups
24 Participants
are divided into 1 treatment groupSponsors and collaborators
Source ClinicalTrials.gov