A Prospective Observational, Multi-Center, Real-World Pharmacological Study Evaluating Adherence to Guideline-Directed Medical Therapy Using the Four-Pillar Strategy in Patients with Advanced Heart Failure
Age > 18 and < 75 years
Heart failure with left ventricular ejection fraction ≤ 35%
Persistent symptoms of heart failure, New York Heart Association class III or IV
Requirement for high-dose diuretic therapy, specifically Furosemide > 50 mg/day orally as per routine clinical practice
Age ≤ 18 years or ≥ 75 years
Left ventricular ejection fraction > 35%
Mild or absent symptoms (New York Heart Association class I-II)
Good response to optimized conventional guideline-directed medical therapy