The goal of this study is to test the efficacy of a rapid bedside blood test in determining if a stroke is happening in children who present to the emergency department with stroke symptoms. The main questions it aims to answer are:
* To determine the sensitivity of detecting a large vessel occlusion (LVO) as the etiology of acute ischemic stroke (AIS) in a pediatric population using a point-of-care blood-based assay (LVOne). * To determine the positive predictive value (PPV) of LVOne in a pediatric population
Participants will:
* Provide a small sample of blood to be used to test the accuracy of the device. * Participants will still receive all standard of care work-up for stroke, which could include computed tomography/magnetic resonance imaging (CT/MRI).
Presenting with acute onset (<18 hours) spontaneous (no trauma) focal neurologic deficit or altered consciousness
Participants with surgery in the past month
Participants with known trauma in the past month
Participants with known seizure history or anti-seizure medications
Participants who are adults with decisional impairment