This clinical trial evaluates deoxyribonucleic acid (DNA) methylation signatures in diagnosing and managing thyroid nodules. The purpose of this research is to develop a new test for thyroid cancer. This test will use needle biopsies (small collections of tissue with a needle) from the thyroid to determine whether the participant has a malignant (cancer) or benign (not showing cancer) thyroid tumor. The information learned from this trial may help develop a more accurate test so that patients do not have unnecessary surgeries for nodules that are thought to be suspicious but are actually benign.
Patients without impaired decision-making capacity and who are undergoing needle biopsies for thyroid nodule diagnosis
Over the age of 18
Any gender, race and ethnicity
Patients must provide informed consent prior to use of their tissues and clinical data
Children are excluded from the study, since the biology of children thyroid nodules is different from adults
City of Hope Medical Center
Lead sponsor
National Cancer Institute (NCI)
Collaborator