Evaluation of Fentanyl Transdermal Patch Absorption in Hemodynamically Unstable ICU Patients.

Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18-70
SponsorTel-Aviv Sourasky Medical Center

About this trial

This study investigates how well fentanyl is absorbed through the skin when delivered via a transdermal patch in critically ill surgical ICU patients. It compares hemodynamically stable patients with unstable patients who require vasopressors to maintain adequate blood pressure. Fentanyl blood levels will be measured over time to assess whether absorption is impaired in unstable patients. The goal is to determine whether transdermal fentanyl is a viable option for pain management in resource-limited ICUs or in situations where intravenous fentanyl is unavailable.

Eligibility criteria

Qualifiers

Adults aged 18-70 years.

Male or female patients.

Admitted to the surgical intensive care unit (ICU).

Indications for pain management using fentanyl.

Disqualifiers

No clinical indication for fentanyl analgesia (e.g., pain well controlled with non-opioid medications).

Known allergy or hypersensitivity to fentanyl.

Contraindications to fentanyl (e.g., severe constipation, hepatic failure)

Patients infected with multidrug-resistant organisms require high-level isolation (biosafety level 2 or higher).

Trial design

Treatments tested in this trial

  • Transdermal fentanyl patch
  • Transdermal fentanyl patch

Treatment groups

40 Participants
are divided into 2 treatment groups